Abstract: Gonadotoxicity is one of the most distressing side effects of cancer treatment. Fertility
preservation strategies should be included during the treatment pathway to prevent the risk of
infertility, but the decision to preserve fertility often represents a challenging process that carries
an emotional decision-making burden. The aim of this study is to characterize the psychological
profiles of women undergoing fertility preservation counseling and to better understand their features.Eighty-two female cancer patients were included in the study. They were asked to complete a battery of self-administered tests which evaluated socio-demographic characteristics, defense mechanisms, depression, anxiety, and representations regarding the importance of parenthood. Based on the psychometric variables, cluster analysis identified four groups which showed significantly different combinations of these psychological characteristics. An additional analysis was performed to evaluate if sociodemographic variables were associated with the four groups, but the results did not show significant differences. These results suggest that very diverse psychological profiles may lead cancer patients to attend oncofertility counseling and choose fertility preservation. For this reason, all patients in childbearing age should have the opportunity to receive appropriate fertility preservation counseling in order to make an informed decision that could have an important impact on their long-term quality of life.